Validation of LOH profiles for assessing oral cancer risk.
نویسندگان
چکیده
This perspective examines the report by Zhang and colleagues in this issue of the journal (beginning on page 1081) on the validation and refinement of a set of risk markers for oral premalignant lesion progression that incorporates loss of heterozygosity markers. The perspective also discusses some of the challenges and opportunities of incorporating predictive biomarkers into monitoring and refined enrollment criteria for prevention studies.
منابع مشابه
Genetic driver events in premalignancy: LOH validated for marking the risk of oral cancer.
In this issue of the journal (beginning on page 1081), Zhang and colleagues extend the 30-year-old discovery of LOH profiles to provide validated markers of oral premalignant lesion risk for cancer. They prospectively show a dramatic difference in cancer progression between high-risk lesions (LOH) and low-risk (non-LOH) lesions (P = 0.002). This work has important implications for oral cancer p...
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ورودعنوان ژورنال:
- Cancer prevention research
دوره 5 9 شماره
صفحات -
تاریخ انتشار 2012